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What Is Calcium Alpha-Ketoglutarate?
What Is Calcium Alpha-Ketoglutarate?
Alpha-ketoglutaric acid and calcium are combined to create calcium alpha-ketoglutarate. An organic acid called alpha-ketoglutaric acid participates in the Krebs cycle, a set of chemical .processes in cells to provide energy. Calcium alpha-ketoglutarate is frequently taken as a dietary supplement to support strong bones and joints, enhance exercise performance, and speed up muscle recovery. Moreover, it is occasionally added to food to enhance specific products’ nutrition.
Calcium alpha-ketoglutarate Specification:
- Chemical formula: C5H4CaO5·H2O
- CAS no. 71686-01-6
- Molecular weight: 202.17 g/mol
- Calcium content: around 9-10% by weight
- Appearance: white to off-white powder
- Solubility: soluble in water
- pH (1% solution): 6.5-8.5
- Heavy metal content: <10 ppm
- Loss on drying: <5%
- Assay (by titration): >98%
Is Alpha Ketoglutarate Activated By Calcium?
The complexes formed by alpha-ketoglutarate (AKG) and various metal ions, such as calcium, can have various biological effects. Calcium alpha-ketoglutarate is widely used as a dietary supplement due to its possible health benefits.
Alpha-ketoglutarate can be made more stable and soluble by adding calcium, and in some circumstances, this may also increase its biological activity. Calcium alpha-ketoglutarate, for instance, has been demonstrated to maintain strong bones and joints and enhance athletic performance and muscle recovery.
The effects of calcium alpha-ketoglutarate can differ based on the dose, the person’s health, and other variables, so it’s crucial to keep that in mind. More research is required to comprehend the mechanisms of action of calcium alpha-ketoglutarate fully and to ascertain its possible advantages and disadvantages.
What Is The Natural Source Of AKG Powder?
The powdered alpha-ketoglutarate (AKG) can be made from natural and artificial sources.
Animal items like meat, fish, and dairy are natural sources of AKG. The body can also produce AKG when metabolizing amino acids, particularly glutamate.
Chemical synthesis or fermentation employing microorganisms like Corynebacterium glutamicum or Pseudomonas fluorescens are two ways to make synthetic AKG powder. The resultant powder is offered online as a dietary supplement in health food stores.
How To Manufacture Ca-AKG Bulk Powder?
To produce Ca-AKG bulk powder, the following general processes may be taken:
- Synthesis of alpha-ketoglutaric acid
Alpha-ketoglutaric acid (AKG) can be produced chemically or by microbial fermentation. Usually, a liquid form of the AKG is created.
- Formation of calcium alpha-ketoglutarate
Calcium alpha-ketoglutarate is created by mixing the AKG solution with a calcium source, such as calcium carbonate or hydroxide. The reaction can be conducted in a controlled environment for temperature, pH, and agitation.
- Filtration and drying
The resulting calcium alpha-ketoglutarate solution is purified by filtering, drying, and ground into a powder. Numerous drying techniques, such as vacuum, freeze, and spray drying, can be utilized.
- Testing and quality control
Ca-AKG powder is tested to ensure it satisfies purity, particle size, calcium content, and other characteristics. For usage as a dietary supplement, the substance may be presented in bulk containers or individual servings.
What Is Alpha-Ketoglutarate Used For The Synthesis Of?
The versatile chemical alpha-ketoglutarate (AKG) is a precursor for synthesizing many other substances, including amino acids, neurotransmitters, and molecules involved in energy. The following are some instances of AKG being employed in synthesis:
Amino acids
AKG can be transformed into glutamate, a non-essential amino acid necessary for the production of proteins and metabolism. Furthermore, glutamate can be transformed into amino acids like arginine, proline, and histidine.
Neurotransmitters
The neurotransmitter gamma-aminobutyric acid can be produced from glutamate, which can be produced from AKG (GABA). GABA is an inhibitory neurotransmitter that affects anxiety, sleep, and mood.
Energy-related molecules
The Krebs cycle, a set of chemical events in cells to produce energy, uses AKG as a crucial intermediary. Succinyl-CoA, a precursor for producing heme, a component of hemoglobin and other proteins, can be produced from AKG.
Pharmaceuticals
Many pharmacological molecules, such as antibiotics and antihypertensive drugs, have been synthesized using AKG as a starting material.
Is Ca AKG Anti-Aging?
The anti-aging supplement calcium alpha-ketoglutarate (Ca-AKG) is occasionally advertised. However, there is little proof that it works.
By enhancing energy metabolism, lowering oxidative stress, and fostering healthy bones and joints, Ca-AKG is suggested to enhance healthy aging. More studies are required to substantiate the effects of Ca-AKG supplementation on exercise performance, muscular recovery, and cognitive function in older persons.
Additionally, some evidence supports the notion that Ca-AKG may encourage collagen formation and enhance skin health, both of which may lessen the appearance of aging. The ideal Ca-AKG supplementation dosage and time frame must be determined through further study.
It’s important to remember that the aging process is intricate and varied, and no one supplement or therapy can completely stop or reverse it. Instead of relying on a single product or intervention, maintaining better aging is supported by a healthy lifestyle, regular exercise, a balanced diet, and stress management.