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Factory Supply Piperaquine Phosphate
Factory Supply Piperaquine Phosphate
Name | Piperaquine phosphate |
Synonyms | 1,3-Bis[1-(7-chloro-4-quinolyl)-4'-piperazinyl]propane tetraphosphate tetrahydrate |
Brand | IdoBio |
Molecular Formula | C29H32Cl2N6.4(H3PO4).4(H2O) |
Molecular Weight | 999.56 |
CAS Registry Number | 4085-31-8 |
Piperaquine is an antimalarial drug, a bisquinoline first made in the 1960s, and used extensively in China and Indochina as prophylaxis and treatment during the next 20 years. Usage declined in the 1980s as piperaquine-resistant strains of P. falciparum arose and artemisinin-based antimalarials became available. However, Chinese scientists have been studying whether piperaquine can still be used therapeutically in combination with artemisinin.
Piperaquine is characterized by slow absorption and a long biological half-life, making it a good partner drug with artemisinin derivatives which are fast acting but have a short biological half-life.
Item | Specification |
Specific rotation | +39.5 to +41.5° |
State of solution(transmittance) | Clear 98.0% min. |
Chloride[cl] | 0.020% max. |
Ammonium [NH4] | 0.02% max. |
Sulfate[SO4] | 0.020% max |
Iron[Fe] | 10ppm max. |
Heavy metals [Pb] | 10ppm max |
Arsenic[As2O3] | 1ppm max |
Other amino acids | Chromatographically not detectable |
Loss on drying | 0.20% max. |
Residue on ignition[sulfated] | 0.10% max. |
Assay | 99.0% min |
1. For the treatment of chloroquine-sensitive falciparum malaria, vivax malaria and three malaria.
2. Can be used for the prevention of malaria symptoms.
3. Can also be used for the treatment of parenteral amoebiasis, connective tissue disease, light-sensitive diseases (such as sunburn erythema) and so on.