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Arecoline Hydrobromide
High Quality Arecoline Hydrobromide
Productname:ArecolineHydrobromidePowder |
CAS No.: 300-08-3 |
Assay: HPLC/ESI-MS |
Molecular formula : C8H13NO2.HBr |
Molecular weight : 236.11 |
Appearance: White fine powder |
Arecoline is a natural alkaloid that is found in the betel nut of the Areca palm. It is an agonist of the muscarinic acetylcholine receptors with EC50 values of 7, 95, 11, 410, and 69 nM for M1, M2, M3, M4, and M5, respectively. Generally, arecoline causes smooth muscle contraction. Arecoline and other muscarinic receptor agonists have been shown to improve learning and memory and may prove to be useful in treating dementia.
(1) It has the heart stimulating effectarecoline hydrobromide.
(2) Anti-cancer and anti inflammatoryarecoline hydrobromide.
(3) It can be used to local anesthesia, refrigeration, anti-inflammation anddetumescencearecolinehydrobromide.
(4)It used in sweating profusely with body temperature dropping; muscle spasm in choleraarecoline hydrobromide.
(5)It used in the treatment of rheumatism, intermittent fevers and acute inflammatory infectionsarecoline hydrobromide.
Owing to its muscarinic and nicotinic agonist properties, arecoline has shown improvement in the learning ability of healthy volunteers. Since one of the hallmarks of Alzheimer's disease is a cognitive decline, arecoline was suggested as a treatment to slow down this process and arecoline administered intravenously did indeed show modest verbal and spatial memory improvement in Alzheimer's patients, though due to arecoline's possible carcinogenic properties,it is not the first drug of choice for this degenerative disease.
Arecoline has also been used medicinally as an antihelmintic (a drug against parasitic worms).