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Rocuronium Bromide
High Quality Rocuronium Bromide
Name |
Rocuronium bromide, CAS 119302-91-9 |
Other name |
ROCURONIUM BROMIDE |
CAS NO. |
119302-91-9 |
Molecular Formula |
C32H53BrN2O4 |
Molecular Weight |
609.69 g/mol |
Appearance |
White or off-white powder |
Melting point |
162-164℃ |
Solubility |
H2O: soluble100mg/mL, clear, light yellow |
Items |
Specifications |
Results |
Description |
Almost white or pale yellow, slightly pink, slightly hygroscopic crystalline powder |
pale yellow |
Solubility |
Freely soluble in water and in anhydrous ethanol |
complies |
Identification |
(1)IR Spectrum conforms with RS |
Complies |
(2)gives reaction of bromides |
Complies |
|
Appearanceof solution |
Dissolve 0.10 g in carbon dioxide-free water R and dilute to 10 ml with the same solvent. Solution is clear |
Complies |
Solution is not more intensely colored than reference solution |
Complies |
|
pH |
8.9~9.5 |
9.18 |
Specific optical rotation |
+ 28.5°~ + 32.0° |
+29.6° |
Related substances |
Individual known impurities (A, B, C)≤0.2%; (F, G, H)≤0.15% |
A:0.03%; F: 0.08%; C0.087, H,B,G:not found(≤0.05%); |
Individual unknown impurity ≤0.1% |
Complies |
|
Total impurities ≤1.0% |
<1%, Complies |
|
Chlorides |
≤0.1% |
0.05% |
Residual solvents
|
Methylene chloride ≤600ppm |
≤390ppm |
Methanol≤3000ppm |
1860ppm |
|
Ethyl ether ≤5000ppm |
≤30ppm |
|
MTBE ≤5000ppm |
630ppm |
|
Ethyl acetate≤5000ppm |
≤30ppm |
|
Heavy metals |
≤20ppm |
Complies |
Water |
≤4.5% |
3.3% |
Sulphated ash |
≤0.1% |
0.05% |
Endotoxins |
≤7EU/mg |
<2EU/mg |
Assay |
99.0%~101.0% |
99.4% |
Conclusion |
The material complies to specifications given above |
Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants.