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Pharmaceutical Grade Powder L-Serine
Pharmaceutical Grade Powder L-Serine
Serine (abbreviated as Ser or S) encoded by the codons UCU, UCC, UCA, UCG, AGU and AGC is an amino acid that is used in the biosynthesis of proteins. It contains an amino group (which is in the protonated −NH+3 form under biological conditions), a carboxyl group (which is in the deprotonated –COO−form in physiological conditions), and a side chain consisting of a hydroxymethyl group (see hydroxyl), classifying it as a polar amino acid. It can be synthesized in the human body under normal physiological circumstances, making it a nonessential amino acid.
Item |
Standard |
Appearance |
White Crystal Power |
Transmittance |
>98.0% |
Chloride (Cl) |
≤0.020% |
Sulfate (SO4) |
≤0.020% |
Iron(Fe) |
≤0.001% |
Heavy Metals (Pb) |
≤0.001% |
Other Amino Acids |
Chromatographically not detectable |
Loss on Drying |
≤0.20% |
Residue in Ignition |
≤0.10% |
Assay |
98.5-101.0% |
1).Serine is important in metabolism in that it participates in the biosynthesis of purines and pyrimidines. It is the precursor to several amino acids including glycine and cysteine, and tryptophan in bacteria. It is also the precursor to numerous other metabolites, including sphingolipids and folate, which is the principal donor of one-carbon fragments in biosynthesis.
2).Serine plays an important role in the catalytic function of many enzymes. It has been shown to occur in the active sites of chymotrypsin, trypsin, and many other enzymes. The so-called nerve gases and many substances used in insecticides have been shown to act by combining with a residue of serine in the active site of acetylcholine esterase, inhibiting the enzyme completely.
3).Serine sidechains are often hydrogen bonded; the commonest small motifs formed are ST turns, ST motifs (often at the beginning of alpha helices) and ST staples (usually at the middle of alpha helices).
As a constituent (residue) of proteins, its side chain can undergo O-linked glycosylation, which may be functionally related to[clarification needed] diabetes.
4).D-serine was thought to exist only in bacteria until relatively recently; it was the second D amino acid discovered to naturally exist in humans, present as a signalling molecule in the brain, soon after the discovery of D-aspartate. Had D amino acids been discovered in humans sooner, the glycine site on the NMDA receptor might instead be named the D-serine site. Apart from central nervous system, D-serine plays a signaling role in peripheral tissues and organs such as cartilage, kidney and corpus cavernosum.
5).L-Serine is sweet with minor umami and sour tastes at high concentration.Pure D-serine is an off-white crystalline powder with a very faint musty aroma. D-Serine is sweet with an additional minor sour taste at medium and high concentrations.
*Pharmaceutical field
L- serine widely used to configure the third-generation compound amino acid infusion and nutritionalb supplements, and for the synthesis of a variety of silk amino acid derivatives, such as cardiovascular, cancer, AIDS and genetic engineering of new drugs and other protected amino acids;
*Food and beverage Field
L- serine can be used to sports drinks, amino acids diet drinks